Protein Details: P2X purinoceptor 2

Protein ID

ICDB_Pro_1657

Protein Name

P2X purinoceptor 2

Gene Name

P2RX2; P2X2

Organism

Homo sapiens (Human)

Length

471 amino acids

AlphaFoldDB

AF-Q9UBL9-F1-model_v4.pdb

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium;sodium and calcium. Activation by extracellular ATP induces a variety of cellular responses;such as excitatory postsynaptic responses in sensory neurons;neuromuscular junctions (NMJ) formation;hearing;perception of taste and peristalsis (By similarity). In the inner ear;regulates sound transduction and auditory neurotransmission;outer hair cell electromotility;inner ear gap junctions;and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity).

Sequence

MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 81; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 83; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 196; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 296; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 300; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 302; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"; BINDING 319; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P56373"

Disease

Deafness;Autosomal Dominant 41 and Rare Autosomal Dominant Non-Syndromic Sensorineural Deafness Type Dfna

Location

Expressed in both the central and peripheral nervous system;as well as in the pituitary gland

DOI ID

10.1124/mol.56.6.1171; 10.1038/nature04569; 10.1073/pnas.1222285110; 10.1016/j.gene.2013.10.052; 10.1073/pnas.1912156116

RefSeq

NP_001269093.1 [Q9UBL9-7]; NP_001269094.1; NP_036358.2 [Q9UBL9-6]; NP_057402.1 [Q9UBL9-3]; NP_733782.1 [Q9UBL9-1]; NP_733783.1 [Q9UBL9-4]; NP_777361.1 [Q9UBL9-5]; NP_777362.1 [Q9UBL9-2]